With no excercise and eating loads of junk food, Frank (Murray) is not taking
care of himself. And although he doesn't realize it, there is a whole population
living inside him that depend on his health.
In The City of Frank, lives millions of blood cells. Among them is Osmosis
Jones (Rock), a sarcastic, street-smart white blood cell and an officer of the
FrankPD. When an evil virus named Thrax (Fishburne) enters Franks body, it's up to
Osmosis to hunt him down. Meanwhile, Frank's daughter has become concerned for
his health, and gives him some cold medication, which provides Osmosis with a partner,
Unfortunately his new by-the-book partner, Drix has only twelve hours
of time-released germ-fighting power, so they must work quickly to find Thrax and get
him out of Frank's system.
||Chris Rock, Joel Silver, Bill Murray, David Hyde Pierce, Molly Shannon, Ron Howard, Laurence Fishburne, William Shatner, Brandy , Ben Stein, Chris Elliott
||The Farrelly Brothers
||Bobby Farrelly, Bradley Thomas, Dennis Edwards, Peter Farrelly
||Marc Hyman, Fergal Reilly