In the tranquil mountain town of Timberline, Boog, (Martin Lawrence), a grizzly bear with no survival skills, enjoys an idyllic existence. He spends his days as the star of the town's nature show and his nights living a life of luxury in the garage of Park Ranger Beth (Debra Messing), who raised him since he was a cub.
Every town has a bully and Timberline's is the paranoid über-hunter Shaw (Gary Sinise). Shaw believes that animals are conspiring against humans, "So we have to get them before they get us!" When he drives into town with Elliot, (Ashton Kutcher), a scrawny, fast-talking wild mule deer strapped to the hood of his truck, Boog is moved by Elliot's pleas for help and against his better judgment, frees him.
Elliot follows Boog home, intent on returning the favor by "freeing" Boog from his garage "captivity." He introduces the bear to a world of sweet temptations he has never known. But when the bear's true instincts being to emerge, events quickly spin out of control.