Minkey, a chimpanzee, and his partner Mike Muggins (Chris Potter) are the best there is at "The Agency.” For these two Spymates, all missions are considered possible. But when their last mission gets too hairy, Mike decides to leave the dangerous world of spy espionage to take care of his daughter Amelia (Emma Roberts). Head down and knuckles dragging, Minkey heads off and joins the circus. It doesn't take long before he’s the star attraction.
Ten years pass. Mike is an insurance salesman living with his 12-year-old daughter Amelia, who has a passion for inventions. Amelia creates the prototype to a revolutionary chemical drill and is honored with the National Scientific Achievement Award. Presenting the award to Amelia is her greatest hero, Dr. Farley (Richard Kind). He invites her to his Scientist Conference in Japan. Farley is secretly building a full-scale version of Amelia's drill, to unleash the worlds' most powerful energy source at the Earth's core. It could, however, cause a massive earthquake, destroying Japan.
Mike and Minkey must partner up one last time for their most important mission ever… to save Amelia!