In Theaters September 12, 2014

Living separate lives on opposite sides of the country, estranged siblings Maggie (Kristen Wiig) and Milo (Bill Hader) are at the end of their ropes. But after a moment of crisis reunites them, Milo goes to spend time with Maggie in the small New York town where they grew up. A dental hygienist, Maggie struggles with her unhappy marriage to the painfully good-natured Lance (Luke Wilson), while Milo tracks down Rich (Ty Burrell), the English teacher with whom he shares a checkered past. Adrift and wondering how they ended up so far from who they were supposed to be, the siblings try to patch things up.