When New York City is taken over by the evil Shredder and his Foot Clan, four unlikely outcast brothers rise from the sewers and discover their destiny as Teenage Mutant Ninja Turtles.

Turtles Michelangelo, Leonardo, Raphael and Donatello must work with fearless reporter April O'Neil (Megan Fox) and her cameraman Vern Fenwick (Will Arnett) to save the Big Apple and put a stop to Shredder's diabolical plan.